Neurological diseases are on the rise – and as societies age, they affect an ever-increasing number of people, not only in Europe, but worldwide.;xNLx;;xNLx;The Munich Cluster for Systems Neurology (SyNergy) investigates how complex neurological diseases such as Alzheimer's disease, stroke, and multiple sclerosis develop.;xNLx;;xNLx;www.synergy-munich.de
In his ERC project, Kerschensteiner plans to use state-of-the-art in vivo microscopy to determine how the structure and function of neural circuits are disrupted by FAD, and then hopes to identify the effector molecules that initiate the process of axonal degeneration.
The first paper with a SyNergy affiliation (published in EMBO Journal) - and a true collaborative work with several members of the cluster (Kremmer, Dormann, Haass). Additionally, Christian Haass took the photo of the current EMBO issue.
The Cluster officially starts. Research projects begin and administratives structures will be set-up.
With Prof. Martin Kerschensteiner, LMU Munich succeeded - with support of the SyNergy Excellence Cluster - to retain a widely recognized leader in neuroimmunological research Prof. Kerschensteiner now co-directs the Institute of Clinical Neuroimmunology at LMU together with Prof. Reinhard Hohlfeld. Kerschensteiner's research, which among other is supported by a Consolidator Grant of the European Research Council, focuses on the mechanisms by which neurons are damaged in neuroinflammatory conditions, and how the innate immune system contributes to such damage. The Kerschensteiner lab utilizes state-of-the-art in vivo imaging technology, neuromorphological analysis and a range of multiple sclerosis animal models.
Eibsee Meeting 2012 “Molecular Mechanisms of Neurodegeneration”
Thomas Misgeld (Technische Universität München) has been awarded the Alzheimer's Research Prize of the Frankfurt-based Hans und Ilse Breuer Stiftung.
SyNergy supported the promotion of Prof. Jochen Herms to the Chair of Translational Brain Research at DZNE and LMU. Prof. Herms is a neuropathologist and an internationally renown researcher in the field of pathomechanistic studies of neurodegeneration. He has pioneered the use in vivo two-photon imaging to study the dynamics that underlie structural and functional deficits in animal models of neurodegenerative disorders such as Alzheimer's disease.
TUM-IAS Carl von Linde Senior Fellow Prof. Arthur Konnerth of the Friedrich-Schiedel Endowed Chair of Neuroscience has received a grant worth 2.4 million Euros. He will analyze memory and learning disorders in Alzheimer’s sufferers.
Max Planck researchers (MPI Biochemistry and Neurobiology) receive 13.9 million Euros in funding for research in neurodegenerative diseases. The ERC Synergy Grant is the most highly endowed research grant of the European Union.
SyNergy-Coordinator Professor Christian Haass has received an Advanced Investigator Grant, worth up to 2.5 million Euros, from the European Research Council (ERC) with the project “Identification and modulation of pathogenic Amyloid β-peptide species”.
Enigmatic aggregates linked to neurodegenerative diseases. SyNergy Scientists identify translation error tracked in the brain of dementia patients.
The festive topping-out ceremony with the Bavarian State Minister for Education and Culture Dr. Ludwig Spänle. The Center of Stroke and Dementia Research (CSD) will host the Institute for Stroke and Dementia Research (ISD), the German Center for Neurodegenerative Diseases (DZNE), and the SyNergy Cluster. Move-in into the new building is expected for spring 2014. (Find out more in German)
LMU researchers and SyNergy Scientists identify a novel signal transduction pathway, which activates the parkin gene and prevents stress-induced neuronal cell death (with cover design of Molecular Cell Volume 49, Issue 5)
SyNergy Member Andreas Ladurner investigates how cells react to stress by alerting well known defense and repair systems, but how the alarm is turned off has long remained a mystery. The crucial enzymes involved have now been identified, and if one of them is missing it causes a serious neurodegenerative disease.
SyNergy Member Arthur Konnerth and his colleagues clarify where and how the brain's "slow waves" originate.
At the Kick-Off Meeting SyNergy Tandem Projects have been introduced for the first time. 23 proposals focus on links between the pathomechanisms of degeneration, inflammation and glio-vascular dysfunction, ranging from basic to clinical research.
New insights into the causes of dementia - Shortage of protein TDP-43 causes muscle wasting and stunted nerve cells.
For the first time, SyNergy Member Magdalena Götz and her colleagues have succeeded in tracking cellular wound responses following an injury to the brain in vivo, in other words, in a live organism, and detected a profound heterogeneity in astrocytes’ function.
Sirko S, Behrendt G, Johansson PA, Tripathi P, Costa M, Bek S, Heinrich C, Tiedt S, Colak D, Dichgans M, Fischer IR, Plesnila N, Staufenbiel M, Haass C, Snapyan M, Saghatelyan A, Tsai LH, Fischer A, Grobe K, Dimou L, Götz M.
During fetal development of the mammalian brain, the cerebral cortex undergoes a marked expansion in surface area in some species, which is accommodated by folding of the tissue in species with most expanded neuron numbers and surface area. Researchers of the SyNergy Cluster have now identified a key regulator of this crucial process published in Cell.
The tight wrapping of genomic DNA around nucleosomes in the cell nucleus makes it unavailable for gene expression. An LMU team now describes a mechanism that allows chromosomal DNA to be locally displaced from nucleosomes for transcription.
SyNergy established new quarter-annuallly Grand Rounds combining neurological case studies with current insights in the pathomechanisms of neurological diseases. The first SyNergy Grand Rounds is on Progranulin and neurodegeneration.
Mitochondria, the organelles that supply the cell with energy, are highly dynamic and can link up to form complex tubular networks. A new study shows that this response can transiently compensate for a shortfall in energy production.
ELSC International School in "In-vivo Intracellular Recordings" at the Institute for Marine Sciences in Eilat, Israel, co-organised by the SyNergy cluster
Special Event with Alzheimer society, DZNE, SyNergy and LMU. Researchers of the SyNergy cluster invite dementia patients to their labs and for discussion about their work.
Arthur Liesz and his team have joined the Institute for Stroke and Dementia Research at the University Hospital of the Ludwig Maximilians University. He will establish a Clinician-Scientist Group on Stroke-Immunology that is funded by the Clinician Scientist Program (CSP) of the SyNergy Cluster.
Neural stem cells in the adult brain have the capacity to differentiate into distinct cell types, giving rise to both nerve cells and glia. A new study has identified a set of proteins that is essential for acquisition of the neuronal cell fate.
SyNergy Researchers have taken a significant step toward the understanding of how mature oligodendrocytes are generated in the adult brain. This is of great importance as loss of these cells leads to several debilitating diseases, including multiple sclerosis.
The European Research Council (ERC) has awarded one of the highest research grants, an ERC Advanced Grant, to Professor Dr. Magdalena Götz, SyNergy-PI and director of the Institute of Stem Cell Research at Helmholtz Zentrum München.
A former monastery in Bavaria – now turned into conference venue – was the site of the recent “Kloster Seeon meeting on BACE proteases in health and disease“ (October 6-8, 2013), organized by Stefan Lichtenthaler from SyNergy.
SyNergy stellt zusammen mit den Münchner Exzellenzclustern am Tag der offenen Tür in Garching seine Forschung vor.
Stange A, Myoga MH, Lingner A, Ford MC, Alexandrowa O, Felmy F, Pecka M, Siveke I, Grothe B.
SyNergy member Dieter Edbauer has been awarded the Alzheimer's Research Prize of the Frankfurt-based Hans und Ilse Breuer Stiftung.
The Eibsee Meeting 2013 “Molecular Mechanisms of Neurodegeneration” cover topics with talks and poster presentation on e.g. neurovascular and neuroimmunology subjects co-organised and sponsored by the SyNergy cluster.
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The Schering Foundation has awarded the Ernst Schering Prize 2014 to the SyNergy member Magdalena Götz, Professor of Physiological Genomics at LMU and Director of the Institute for Stem Cell Research at the Helmholtz Center Munich.
The progress a baby makes in the first year of life is amazing: a newborn can only wave its arms and legs about randomly, but not so long after the baby can reach out and pick up a crumb from the carpet.
Mareike Mitsdoerffer will establish a Clinician-Scientist Group at the Department of Neurology at the University Hospital of the Technical University Munich that is funded by the Clinician Scientist Program (CSP) of the SyNergy Cluster.
“Professor Haass has done great service for the good of all with his outstanding performance in the fields of science and research and his dedication to the university city of Munich,” says the Bavarian State Minister’s laudation.
Snaidero N, Möbius W, Czopka T, Hekking LHP, Mathisen C, Verkleij D, Goebbels S, Edgar J, Merkler D, Lyons DA, Nave KA, Simons M.
SyNergy member Dieter Edbauer from the Munich site of the German Center for Neurodegenerative Diseases (DZNE) has been awarded a “Consolidator Grant” worth approximately two million Euro by the European Research Council (ERC). This award goes to young researchers whose projects are breaking new scientific ground. Edbauer will be using this financial support to investigate brain diseases currently deemed incurable and develop measures to treat them.
SyNergy member Rüdiger Klein from the Max Planck Institute of Neurobiology in Martinsried and his colleagues from the Max Planck Institute of Molecular Physiology in Dortmund have now been able to artificially trigger and study the formation of groups of Eph receptors in cell culture
Neurodegenerative diseases like Parkinson’s disease involve the death of thousands of neurons in the brain. Nerve growth factors produced by the body, such as GDNF, promote the survival of the neurons; however, clinical tests with GDNF have not yielded in any clear improvements.
Francisco Pan-Montojo and his team have joined the Department of Neurology at the University Hospital of the Ludwig Maximilians University. He will establish a Clinician-Scientist Group on Parkinson’s disease pathophysiology that is funded by the Clinician Scientist Program (CSP) of the SyNergy Cluster.
TUM scientist and co-speaker of the Excellence Cluster "Munich Cluster for Systems Neurology" (SyNergy) Prof. Thomas Misgeld has received a ERC Consolidator Grant, of which provides around two million euros in funding. Prof. Thomas Misgeld leads the laboratory for Biomolecular Sensors, where he investigates the degeneration of nerve fibers.
After a natural disaster like a big fire, countless helpers work together to get rid of debris, to build temporary shelters and to provide food for people in need. When a cell is exposed to dangerous environmental conditions such as high temperatures or toxic substances, a quite similar process is initiated: the cellular stress response, also called heat shock response.
Anton Sirota coming from Tübingen accepted a W3-professorship for Cognition and Neural Plasticity at the Ludwig Maximilians University
Schober A, Nazari-Jahantigh M, Wei Y, Bidzhekov K, Gremse F, Grommes J, Megens RTA, Heyll K, Noels H, Hristov M, Wang S, Kiessling F, Olson EN, Weber C.
In a study published online in Genome Research, SyNergy membersI Profs Winkelmann, Wurst, Meitinger, and Müller-Myhsok and other researchers of the Helmholtz Zentrum München als well as the Technische Universität München have demonstrated that a common genetic variant associated with Restless Legs Syndrome (RLS) alters the expression of a critical gene during fetal development of the brain. This leads to alterations of the developing forebrain indicating an anatomical region involved in RLS.
EMBO Workshop "Mechanisms of neuronal remodelling" in Kibbutz Ein-Gedi, Israel, co-organised by the SyNergy cluster
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