Babylon fell to the Persians at the hands of Cyrus the Great. This brought an end to Mesopotamian dominance of the region between the Tigris and the Euphrates. Mesopotamian cuneiform culture all but disappeared from history in the centuries that followed.
Though relatively short-lived, the Neo-Babylonian empire has the distinction of conquering the Neo-Assyrians. It is perhaps most famous for its king Nebuchadnezzar, who exiled hordes of Judeans to Babylon and conquered Jerusalem. He was also a magnificent builder, who made Babylon world-famous in antiquity for its architecture.
Starting with king Assurnasirpal, the Neo-Assyrian Empire grew to at least four times larger than its size under any previous Assyrian king. At its height, the empire covered modern-day Iraq, Syria, Lebanon, most of Egypt, and parts of Jordan, Israel, Palestine, Turkey, and Iran. Their tactics were harsh, their military fierce. The violent nature of a Neo-Assyrian attack is preserved in reliefs found in Sennacherib's palace, which depict the seige of the Judean town of Lachish.
Judah was able to outlast its more powerful northern neighbor Israel due in part to the fortification projects (and a generous tribute) carried out by King Hezekiah, who the Assyrian king Sennacherib bragged was locked up in Jerusalem "like a bird in a cage." Though most of Judah was laid waste by the Assyrians, Jerusalem survived the siege. Judah could not withstand the Babylonians, however, who destroyed Jerusalem in 586 B.C.E.
Referred to as the House of Omri by sources outside the Bible, the northern kingdom of Israel was a much more formidable regional power than its southern neighbor Judah. Israel was engaged in regional conflicts with its neighbors throughout most of its history, and eventually joined an alliance against the invading Assyrians. But this was to no avail, Israel was destroyed by the Assyrians in 722 B.C.E.
According to the Bible, the kingdom was first lead by King Saul, who died in battle. He was succeeded by David, who made his capital and established a dynasty in Jerusalem. David was succeeded by his son Solomon, who built a temple dedicated to their national deity, Yahweh. The Bible presents Solomon as expanding the kingdom to its largest size. Shortly after his death, the kingdom split into two separate states: Israel to the north and Judah to the south. Even at its height, the kingdom of Israel was no more than a modest regional power.
After a period of decline, Assyria once again rose to prominence in the region, led most notably by king Tukulti-Ninurta. The king had many military victories, including the defeat of Babylon and the deportation of its people; he destroyed the city's walls and temples and removed the statue of Marduk (the patron god of Babylon).
With its capital Hattusa located in Anatolia (modern-day Turkey), the Hittite empire grew to be one of the largest the ancient world had seen until that time. It stretched from the Aegean to the Upper Tigris, and from the Black Sea to Lebanon. Though the Hittite language was Indo-European and not Semitic, the Hittites adopted Mesopotamian cuneiform writing.
In the presence of a power vacuum in Babylon, the throne was seized by people who called themselves Kassites, recent immigrants to the region. Though this group gained political prominence, it is difficult to detect their cultural impact in Babylon. Mesopotamian scribal culture thrived under the Kassites, in fact, it is during this period that the literary dialect of Akkadian known as Standard Babylonian developed and that many of the most important works, such as the Epic of Gilgamesh, were given their standardized form. Standard Babylonian would remain the literary dialect for the rest of Mesopotamian history.
The archives found at Mari have shed light on a previously unknown region and period. Mari is important because of its location on the route between Mesopotamia and Syria. As a result of this location, Mari has the distinction of being culturally both West and East Semitic. While its power structure reflected the palace structure of Mesopotamia, it also reflected the tribal kin-based structure of the west.